My apartment is well connected and central, just next to Termini Station and Mura Aureliane, so there is history all around you. The district is very Roman, real feeling around you, not the like some central places of Rome, which are sometimes too much touristic. There are buses (n.41 and 492) Tram (n.3 and 19) and metro station ( A and B line) very close to the apt. so is a good position to explore Rome.
You can walk to the Colosseum in 20 minutes.