A very comfortable place in Rome Termini.
The colosseum is just 5 minutes walk from this place and lots of public transports are aswell available in walking distance from were if you want to see amazing places like, Venezia Square by bus 10 minutes. Vatican by Tube 15 minutes. Trastevere by bus 15 minutes. Navona Square by bus 15 minutes. Trevi fountain by tube 5 minutes.
Definitely very strategic spot in Rome starting from connections, to get here from Fiumicino and Ciampino airport by train